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Netropsin dihydrochloride
103 人阅读发布时间：2021-03-29 20:09
简介 ：Netropsin (dihydrochloride) is a small-molecule MGB (minor-groove binder), inhibits the catalytic activity of isolated topoisomerase and interferes with the stabilization of the cleavable complexes of topoisomerase II and I in nuclei. Netropsin (dihydrochloride) has potential antibiotic and antiviral properties by binding to dsDNA in a non-intercalative manner, it improves survival from murine endotoxaemia by attenuating NOS2 induction through interference with HMGA1 DNA binding to the core NOS2 promoter. Netropsin (dihydrochloride) in solutions of DNA has radioprotective ability against radiation-induced damage due to its high binding affinity and high structural stabilization, hydroxyl radical (OH*) generated by ionizing radiation cannot radiolyse the netropsin-DNA complex.
Catalog_No：HY-N6800A
Drug_Names：Netropsin dihydrochloride
Alternative_Names：
产品一级分类：天然产物
二级分类：Others
SMILES：O=C(C1=CC(NC(CNC(N)=N)=O)=CN1C)NC2=CN(C)C(C(NCCC(N)=N)=O)=C2.[H]Cl.[H]Cl
Pathway：Cell Cycle/DNA Damage
Target：DNA/RNA Synthesis; Bacterial; Influenza Virus; Antibiotic
Research_Area：Inflammation/Immunology; Infection
国际站：Netropsin dihydrochloride