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T-2 Toxin
189 人阅读发布时间：2021-03-29 20:09
简介 ：T-2 Toxin (T-2 Mycotoxin) is a toxic trichothecene mycotoxin produced by various Fusarium species in feedstuffs and cereal grains, LD50 values of T-2 Toxin in mice and rats are 5.2 and 1.5 mg/kg BWa,respectively . T-2 Toxin (T-2 Mycotoxin) can be transformed into a variety of metabolite, the typical metabolites of T-2 toxin in animals are HT-2 toxin and T-2-triol, which are hydrolysates. T-2 Toxin (T-2 Mycotoxin) is an inhibitor of protein synthesis resulting from binding peptidyltransferase, which is an integral part of the 60s ribosomal subunit. T-2 Toxin (T-2 Mycotoxin) inhibits the synthesis of DNA and RNA, interferes with the metabolism of membrane phospholipids, and increases the level of liver lipid peroxides. T-2 Toxin (T-2 Mycotoxin) induces apoptosis in the immune system, gastrointestinal tissues, and fetal tissues.
Catalog_No：HY-N6792
Drug_Names：T-2 Toxin
Alternative_Names：T-2 Mycotoxin
产品一级分类：天然产物
二级分类：Others
SMILES：CC12C3(CO3)[C@@](O[C@@](/C=C(C)\[C@@H](OC(CC(C)C)=O)C)([H])[C@H]2COC(C)=O)([H])[C@H](O)[C@H]1OC(C)=O
Pathway：Apoptosis
Target：Apoptosis; DNA/RNA Synthesis
Research_Area：Metabolic Disease
国际站：T-2 Toxin