简介 :Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells . Gliotoxin inhibits inducible NF-κB activity by preventing IκB degradation, which consequently induces host-cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus internalization into lung epithelial cells.
Catalog_No:HY-N6727
Alternative_Names:Aspergillin
产品一级分类:天然产物
二级分类:Others
SMILES:O=C1N(C)[C@@]2(CO)C(N3[C@@]1(SS2)CC4=CC=C[C@H](O)[C@@]34[H])=O
Pathway:Apoptosis
Target:Apoptosis; PKA; NF-κB; Bacterial; Fungal; Antibiotic
Research_Area:Inflammation/Immunology; Infection
国际站:Gliotoxin