简介 :Darusentan (Lu-135252) is a selective endothelin receptor A (ET-A) receptor antagonist, which binds with a Ki of 1.4 nM to the ET-A receptor and a Ki of 184 nM to ET-B receptor, respectively with a 100-fold selectivity for ETA rather than ETB receptors. Darusentan competes for radiolabeled endothelin binding in rat aortic vascular smooth muscle cells (RAVSMs) membranes with single-site kinetics, exhibiting a Ki of 13 nM.
Catalog_No:HY-15404
Alternative_Names:Lu-135252
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:COC1=NC(O[C@H](C(O)=O)C(C2=CC=CC=C2)(C3=CC=CC=C3)OC)=NC(OC)=C1
Pathway:GPCR/G Protein
Target:Endothelin Receptor
Research_Area:Endocrinology; Cardiovascular Disease
国际站:Darusentan