简介 :SPP-86 is a potent and selective cell permeable inhibitor of RET tyrosine kinase, with an IC50 of 8 nM. SPP-86 inhibits RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling, also inhibits RET-induced estrogen receptorα (ERα) phosphorylation in MCF7 cells.
Catalog_No:HY-110193
Alternative_Names:
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:CC(C)N1C2=NC=NC(N)=C2C(C#CC3=CC=CC=C3)=N1
Pathway:Protein Tyrosine Kinase/RTK
Target:RET
Research_Area:Cancer
国际站:SPP-86