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Guggulsterone
99 人阅读发布时间：2021-03-30 11:20
简介 ：Guggulsterone is a plant sterol derived from the gum resin of the tree Commiphora wightii. Guggulsterone inhibits the growth of a wide variety of tumor cells and induces apoptosis through down regulation of antiapoptotic gene products (IAP1, xIAP, Bfl-1/A1, Bcl-2, cFLIP and survivin), modulation of cell cycle proteins (cyclin D1 and c-Myc), activation of caspases and JNK, inhibition of Akt. Guggulsterone, a farnesoid X receptor (FXR) antagonist, decreases CDCA-induced FXR activation with IC50s of 17 and 15 μM for Z- and E-Guggulsterone, respectively.
Catalog_No：HY-107738
Drug_Names：Guggulsterone
Alternative_Names：Z/E-Guggulsterone
产品一级分类：天然产物
二级分类：Terpenoids and Glycosides
SMILES：C[C@@]1(/C2=C/C)[C@](CC2=O)([H])[C@@]3([H])[C@]([C@@]4(C(CC3)=CC(CC4)=O)C)([H])CC1
Pathway：Apoptosis
Target：Apoptosis; JNK; Akt; Caspase; FXR; Autophagy
Research_Area：Cancer
国际站：Guggulsterone