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Taccalonolide A
116 人阅读发布时间：2021-03-30 09:19
简介 ：Taccalonolide A is a microtubule stabilizer, which is a steroid isolated from Tacca chantrieri, with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.
Catalog_No：HY-N2416
Drug_Names：Taccalonolide A
Alternative_Names：
产品一级分类：天然产物
二级分类：Steroids
SMILES：C[C@@]12[C@]([C@@H](OC(C)=O)[C@]3([H])[C@]2([H])[C@@H](C=C(O4)[C@@]3([C@](O)(C4=O)C)C)C)([H])[C@@]([C@H]5O)([H])[C@]([C@]6([C@H]([C@@H](O7)[C@@H]7C[C@]6([H])C5=O)OC(C)=O)C)([H])[C@H](OC(C)=O)[C@@H]1OC(C)=O
Pathway：Cell Cycle/DNA Damage
Target：Microtubule/Tubulin; Apoptosis
Research_Area：Cancer
国际站：Taccalonolide A