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Andropanolide
131 人阅读发布时间：2021-03-30 08:55
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简介 ：Andrographolide (Andro) is a small antagonist for NF-κB activation by covalent modifying reduced cysteine 62 of p50. Andrographolide is a bicyclic diterpenoid lactone mainly produced from the plant Andrographis (Andrographis paniculate). Andrographolide suppresses the activation of NF-κB in stimulated endothelial cells, which reduces the expression of cell adhesion molecule E-selectin and prevents E-selectin-mediated leukocyte adhesion, but has no effect on IκBα degradation, p50 and p65 nuclear translocation.
Catalog_No：HY-N1912
Drug_Names：Andropanolide
Alternative_Names：
产品一级分类：天然产物
二级分类：Others
SMILES：O=C1OC[C@@H](O)/C1=C/C[C@@H]2C(CC[C@]3([H])[C@](C)(CO)[C@H](O)CC[C@@]23C)=C
Pathway：NF-κB
Target：NF-κB
Research_Area：Inflammation/Immunology
国际站：Andropanolide