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NS-2028
194 人阅读发布时间：2021-03-29 20:16
简介 ：NS-2028 is a highly selective soluble Guanylyl Cyclase (sGC) inhibitor with IC50 values of 30 nM and 200 nM for basal and NO-stimulated enzyme activity. NS-2028 inhibits soluble Guanylyl Cyclase activity in homogenates of mouse cerebellum and neuronal NO synthase with IC50 values of 17 nM and 20 nM. NS-2028 inhibits 3-morpholino-sydnonimine (SIN-1)-elicited formation of cyclic GMP in human cultured umbilical vein endothelial cells with an IC50 of 30 nM. NS-2028 is commonly used in the research of nitric oxide signaling pathways, it inhibits NO-dependent relaxant responses in non-vascular smooth muscle completely (1 μM). NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability.
Catalog_No：HY-12379
Drug_Names：NS-2028
Alternative_Names：
产品一级分类：信号通路
二级分类：生命科学试剂
SMILES：O=C1ON=C2COC3=CC=C(Br)C=C3N21
Pathway：GPCR/G Protein
Target：Guanylate Cyclase
Research_Area：Inflammation/Immunology
国际站：NS-2028