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Dehydroaltenusin
124 人阅读发布时间：2021-03-29 20:13
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简介 ：Dehydroaltenusin is a small molecule selective inhibitor of eukaryotic DNA polymerase α, a type of antibiotic produced by a fungus with an IC50 value of 0.68 μM. The inhibitory mode of action of dehydroaltenusin against mammalian pol α activity is competitive with respect to the DNA template primer (Ki=0.23 µM) and non-competitive with respect to the 2'-deoxyribonucleoside 5'-triphosphate substrate (Ki=0.18 µM). Dehydroaltenusin arrests the cancer cell cycle at the S-phase and triggers apoptosis. Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumor in vivo.
Catalog_No：HY-100513A
Drug_Names：Dehydroaltenusin
Alternative_Names：
产品一级分类：天然产物
二级分类：Phenols
SMILES：O=C(C(O)=C1)C=C(C2=CC(OC)=CC(O)=C23)[C@@]1(C)OC3=O
Pathway：Apoptosis
Target：Apoptosis; DNA/RNA Synthesis
Research_Area：Cancer
国际站：Dehydroaltenusin