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Brevilin A
72 人阅读发布时间：2021-03-29 19:51
简介 ：Brevilin A is a sesquiterpene lactone isolated from Centipeda minima with anti-tumor activity. Brevilin A is a selective inhibitor of JAK-STAT signal pathway by attenuating the JAKs activity and blocking STAT3 signaling (IC50 = 10.6 µM) in Cancer Cells. Brevilin A induces apoptosis and autophagy via mitochondrial pathway and PI3K/AKT/mTOR inactivation in colon adenocarcinoma cell CT26.
Catalog_No：HY-N2959
Drug_Names：Brevilin A
Alternative_Names：
产品一级分类：天然产物
二级分类：Terpenoids and Glycosides
SMILES：C/C=C(C)\C(O[C@H]1[C@@]([C@@H]2C)([H])[C@@](OC2=O)([H])C[C@@H](C)[C@@]3([H])[C@]1(C(C=C3)=O)C)=O
Pathway：Epigenetics
Target：JAK; STAT; Apoptosis; Autophagy
Research_Area：Cancer
国际站：Brevilin A