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Manumycin A
124 人阅读发布时间：2021-03-29 19:16
简介 ：Manumycin A is an antibiotic. Manumycin A acts as a selective, competitive inhibitor of protein farnesyltransferase (FTase) with respect to farnesylpyrophosphate (Ki =1.2 μM), and as a noncompetitive inhibitor with respect to the Ras protein. Manumycin A induces apoptosis and exerts antitumor activity . Manumycin A suppresses exosome biogenesis and secretion via targeted inhibition of Ras/Raf/ERK1/2 signaling. Manumycin A is a nSMase inhibitor (EC50=0.25 μM).
Catalog_No：HY-N6796
Drug_Names：Manumycin A
Alternative_Names：
产品一级分类：天然产物
二级分类：Others
SMILES：CCCC[C@@H](C)/C=C(C)/C=C(C)/C(NC1=C[C@](/C=C/C=C/C=C/C(NC2=C(O)CCC2=O)=O)(O)[C@]3([H])O[C@]3([H])C1=O)=O
Pathway：Metabolic Enzyme/Protease
Target：Farnesyl Transferase; Ras; Apoptosis; Phospholipase
Research_Area：Infection; Cancer
国际站：Manumycin A