简介 :Paxilline is an indole alkaloid mycotoxin from Penicillium paxilli, acts as a potent BK channels inhibitor by an almost exclusively closed-channel block mechanism. Paxilline also inhibits the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA) with IC50s between 5 μM and 50 μM for differing isoforms. Paxilline possesses significant anticonvulsant activity.
Catalog_No:HY-N6778
Alternative_Names:
产品一级分类:天然产物
二级分类:Alkaloids
SMILES:O=C1[C@@H](C(C)(O)C)O[C@](CC2)([H])C([C@]([C@@]2(C)[C@]34C)(O)CC[C@@]3([H])CC5=C4NC6=C5C=CC=C6)=C1
Pathway:Membrane Transporter/Ion Channel
Target:Potassium Channel; Calcium Channel
Research_Area:Neurological Disease
国际站:Paxilline