简介 :K-252a, a staurosporine analog isolated from Nocardiopsis sp. soil fungi, inhibits protein kinase, with IC50 values of 470 nM, 140 nM, 270 nM, and 1.7 nM for PKC, PKA, Ca2+/calmodulin-dependent kinase type II, and phosphorylase kinase, respectively. K-252a is a potent inhibitor (IC50 of 3 nM) of the tyrosine protein kinase (TRK) activity of the NGF receptor gp140trk, the product of the trk protooncogene.
Catalog_No:HY-N6732
Alternative_Names:SF2370; Antibiotic K 252a; Antibiotic SF 2370
产品一级分类:天然产物
二级分类:Others
SMILES:O=C(NC1)C2=C1C3=C4C5=C2C6=C(C=CC=C6)N5[C@](C[C@]7(O)C(OC)=O)([H])O[C@]7(C)N4C8=C3C=CC=C8
Pathway:Epigenetics
Target:PKC; PKA; CaMK; Trk Receptor; Autophagy
Research_Area:Infection
国际站:K-252a