简介 :JH-RE-06, a potent REV1-REV7 interface inhibitor (IC50=0.78 μM; Kd=0.42 μM), targets REV1 that interacts with the REV7 subunit of POLζ. JH-RE-06 disrupts mutagenic translesion synthesis (TLS) by preventing recruitment of mutagenic POLζ. JH-RE-06 improves chemotherapy.
Catalog_No:HY-126214
Alternative_Names:
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:O=C1C(C(CC(C)C)=O)=C(NC2=CC=C(Cl)C=C2Cl)NC3=C1C([N+]([O-])=O)=CC=C3Cl
Pathway:Cell Cycle/DNA Damage
Target:DNA/RNA Synthesis
Research_Area:Cancer
国际站:JH-RE-06