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Cytochalasin D

161 人阅读发布时间:2021-03-29 17:41

简介 Cytochalasin D (Zygosporin A; NSC 209835) is a potent and cell-permeable inhibitor of actin polymerization derived from fungus, inhibits the G-actin–cofilin interaction by binding to G-actin. Cytochalasin D (Zygosporin A; NSC 209835) also inhibits the binding of cofilin to F-actin and decreases the rate of both actin polymerization and depolymerization in living cells.Cytochalasin D can reduce exosome release, in turn reducing the amount of survivin present in the tumour environment. Cytochalasin D induces phosphorylation and cytoplasmic retention of YAP.
 
Catalog_NoHY-N6682
 
Drug_NamesCytochalasin D
 
Alternative_NamesZygosporin A; NSC 209835
 
产品一级分类天然产物
 
二级分类Others
 

SMILESC=C1[C@@H](O)[C@@]2([H])[C@@]3([C@H](OC(C)=O)/C=C/[C@](O)(C)C([C@@H](C)C/C=C/2)=O)[C@@]([C@H](CC4=CC=CC=C4)NC3=O)([H])[C@@H]1C

PathwayCytoskeleton
 
TargetArp2/3 Complex; Bacterial; Antibiotic; YAP
 
Research_AreaInfection
 
国际站Cytochalasin D

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