简介 :Alsterpaullone (9-Nitropaullone) is a potent CDK inhibitor, with IC50s of 35 nM, 15 nM, 200 nM and 40 nM for CDK1/cyclin B, CDK2/cyclin A, CDK2/cyclin E and CDK5/p35, respectively. Alsterpaullone also competes with ATP for binding to GSK-3alpha/GSK-3beta with IC50s of both 4 nM. Alsterpaullone has antitumor activity, and possesses potential for the study in neurodegenerative and proliferative disorders.
Catalog_No:HY-108359
Alternative_Names:9-Nitropaullone; NSC 705701
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:O=C1NC2=CC=CC=C2C(NC3=C4C=C([N+]([O-])=O)C=C3)=C4C1
Pathway:Cell Cycle/DNA Damage
Target:CDK; GSK-3
Research_Area:Cancer
国际站:Alsterpaullone