简介 :5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.
Catalog_No:HY-128067
Alternative_Names:Hexamethylene amiloride; HMA
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:O=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N
Pathway:Membrane Transporter/Ion Channel
Target:Sodium Channel; HIV; Apoptosis
Research_Area:Infection; Cancer
国际站:5-(N,N-Hexamethylene)-amiloride