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5-(N,N-Hexamethylene)-amiloride

93 人阅读发布时间:2021-03-29 15:06

简介 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) derives from an amiloride and is a potent Na+/H+ exchanger inhibitor, which decreases the intracellular pH (pHi) and induces apoptosis in leukemic cells. 5-(N,N-Hexamethylene)-amiloride (Hexamethylene amiloride) is also an inhibitor of the HIV-1 Vpu virus ion channel and inhibits mouse hepatitis virus (MHV) replication and human coronavirus 229E (HCoV229E) replication in cultured L929 cells with EC50s of 3.91 μM and 1.34 μM, respectively.
 
Catalog_NoHY-128067
   
Alternative_NamesHexamethylene amiloride; HMA
 
产品一级分类信号通路
 
二级分类生命科学试剂
 

SMILESO=C(C1=NC(Cl)=C(N2CCCCCC2)N=C1N)NC(N)=N

PathwayMembrane Transporter/Ion Channel
 
TargetSodium Channel; HIV; Apoptosis
 
Research_AreaInfection; Cancer
 
国际站5-(N,N-Hexamethylene)-amiloride

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