简介 :NSC 95397 is a potent, selective Cdc25 dual specificity phosphatase inhibitor (Ki=32 nM (Cdc25A), 96 nM (Cdc25B), 40 nM (Cdc25C); IC50=22.3 nM (human Cdc25A), 56.9 nM (human Cdc25C), 125 nM (Cdc25B)). NSC 95397 inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) and suppresses proliferation and induces apoptosis in colon cancer cells through MKP-1 and ERK1/2 pathway.
Catalog_No:HY-108543
Alternative_Names:
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:O=C1C(SCCO)=C(SCCO)C(C2=C1C=CC=C2)=O
Pathway:Metabolic Enzyme/Protease
Target:Phosphatase; Apoptosis
Research_Area:Cancer
国际站:NSC 95397