简介 :GR 159897 is a highly potent, selective, competitive, brain-penetrated non-peptide neurokinin 2 (NK2) receptor antagonist. GR 159897 has little or no affinity for NK1 and NK3 receptors. GR 159897 inhibits binding of [3H]GR100679 to human NK2 (hNK2)-CHO cells and rat colon membranes with pKis of 9.51 and 10, respectively. Antagonizes bronchoconstriction. Anxiolytic-like and anti-tumor effects.
Catalog_No:HY-107691
Alternative_Names:
产品一级分类:信号通路
二级分类:生命科学试剂
SMILES:O=[S@](CC1(OC)CCN(CCC2=CNC3=C2C=C(F)C=C3)CC1)C4=CC=CC=C4
Pathway:GPCR/G Protein
Target:Neurokinin Receptor
Research_Area:Neurological Disease; Endocrinology; Cancer
国际站:GR 159897