Ionomycin 钙离子载体 (calcium ionophore)

Ionomycin (SQ23377) 是一种有效的，选择性的钙离子载体 (calcium ionophore)，也是一种由 Streptomyces conglobatus 产生的抗生素。Ionomycin (SQ23377) 对二价阳离子具有高度特异性 (Ca>Mg>Sr=Ba)。Ionomycin (SQ23377) 促进细胞凋亡。Ionomycin (SQ23377) 还诱导蛋白激酶C (PKC) 激活。

产品描述 ：

Ionomycin (SQ23377) is a potent, selective calcium ionophore and an antibiotic produced by Streptomyces conglobatus. Ionomycin (SQ23377) is highly specific for divalent cations (Ca>Mg>Sr=Ba). Ionomycin (SQ23377) promotes apoptosis. Ionomycin also induces the activation of protein kinase C (PKC).

靶点：IC50 & Target     Calcium ionophore[1]


体外实验：

Ionomycin is a Calcium ionophore and an antibiotic produced by Streptomyces conglobatus[1].
Addition of 2 μM Ionomycin to LCLC 103H cells causes an instantaneous increase in intracellular Ca2+ concentration from 50 to 180 nM. DNA and protein analysis in Ionomycin-treated cultures revealed DNA fragmentation and PARP cleavage to an 85-kDa fragment typical of caspase-mediated apoptosis. Necrosis could be detected in ~1-5% of the Ionomycin treated cells. Caspase activation in whole cells was followed by monitoring the increase in activity against Ac-DEVD-amc following Ionomycin treatment[2].
Ionomycin-mediated cleavage and exosome release. Following Ionomycin exposure, medium conditioned by SKOV3ip cells had increased amounts of exosomes containing the L1-32 cleavage fragment[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.