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Ivabradine (hydrochloride)前沿研究进展
354 人阅读发布时间：2018-07-16 14:34
Isoguvacine (hydrochloride)产品描述：Isoguvacine hydrochloride是 GABA 受体激动剂。
Isoguvacine (hydrochloride)产品描述：Isoguvacine hydrochloride is a GABA receptor agonist.IC50 & Target: GABA[1]In Vitro: Isoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus[1]. Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA[2]. Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures. Isoguvacine inhibits the low magnesium induced seizure like events dose dependently[3].
研究领域：GPCR/G Protein
靶点：Endothelin Receptor
相关产品：Macitentan | Atrasentan hydrochloride | BQ-788 sodium salt | Bosentan | Ambrisentan | Avosentan | BQ-123 | ACT-132577 | Sitaxsentan sodium | Sulfisoxazole | Endothelin 1 swine, human | Aminaftone | PD-159020 | Ro 46-2005 | ZD-1611 |
MWt:163.60
Formula:C6H10ClNO2
SMILES:O=C(C1=CCNCC1)O.[H]Cl
Research_Area:Neurological Disease
公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。
MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利；
MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；
数千种产品在上海有充足备货，24-48小时内送达客户；
大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。
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网址：www.medchemexpress.cn
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Isoguvacine (hydrochloride)产品描述：Isoguvacine hydrochloride is a GABA receptor agonist.IC50 & Target: GABA[1]In Vitro: Isoguvacine binds to a mouse forebrain synaptic membrane preparation. The specific binding is displaceable by GABA, muscimol and bicuculline but not by picrotoxin or diaminobutyric acid. Kinetic data suggest two binding affinities. Highest levels of binding are observed in the cerebellum, cortex and hippocampus[1]. Isoguvacine binds to membrane preparations of rat forebrain with pharmacological characteristics similar to the postsynaptic GABA recognition site: that it is transported into synaptosomal preparations by an uptake system similar to the high-affinity GABA uptake system; and that recently accumulated isoguvacine is released in a Ca2+-dependent manner and by heteroexchange with external GABA[2]. Isoguvacine at a concentration of 50 μM blocks the seizure like events in 2 out of 6 organotypic hippocampal slice cultures. Isoguvacine inhibits the low magnesium induced seizure like events dose dependently[3].
研究领域：GPCR/G Protein
靶点：Endothelin Receptor
相关产品：Macitentan | Atrasentan hydrochloride | BQ-788 sodium salt | Bosentan | Ambrisentan | Avosentan | BQ-123 | ACT-132577 | Sitaxsentan sodium | Sulfisoxazole | Endothelin 1 swine, human | Aminaftone | PD-159020 | Ro 46-2005 | ZD-1611 |
MWt:163.60
Formula:C6H10ClNO2
SMILES:O=C(C1=CCNCC1)O.[H]Cl
Research_Area:Neurological Disease
公司介绍：MedChemExpress(MCE)专注于各种抑制剂、激动剂、API及化合物库，总部位于美国新泽西，分别在瑞典和上海设有欧洲区子公司和亚洲区总代理，营销网点遍及全球20多个国家地区。MCE经过多年努力已成为全球生物活性小分子领域的一流供应商， 产品涵盖癌症、神经科学、抗感染、表观遗传学等20个热门研究领域，PI3K、MAPK等近千个细分靶点，超过4000个活性小分子化合物现货，以及GPCR、API、离子通道等超过20种不同类型的化合物库，同时提供从毫克到千克的专业定制合成服务。
MCE 对每批产品都进行严格的LCMS和NMR检验，其产品已被全球近万名客户广泛使用并发表大量文章、专利；
MCE 定期增加各领域热门抑制剂、激动剂，不断扩增已有化合物库，以满足最新的科研需求；
数千种产品在上海有充足备货，24-48小时内送达客户；
大量产品提供免费试用装；已为全球多个知名企业、院校构建各种定制型化合物库。
电话:021-58955995
网址：www.medchemexpress.cn
地址:上海市浦东新区蔡伦路720号2号楼3层