MRT68921前沿研究进展

MRT68921是ULK1和ULK2最有效的抑制剂，IC₅₀值分别为2.9 nM和1.1 nM.
SKF-96365 (hydrochloride)产品描述：SKF-96365 hydrochloride, an SOCE inhibitor, exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells.In Vitro: SKF-96365 exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells. SKF-96365 inhibits hERG current in a concentration-dependent manner^[1]. SKF-96365 can induces cytoprotective autophagy to delay apoptosis by preventing the release of cytochrome c (cyt c) from the mitochondria into the cytoplasm. Mechanistically, SKF-96365 treatment inhibits the calcium/calmodulin-dependent protein kinase IIγ (CaMKIIγ)/AKT signaling cascade. Overexpression of CaMKIIγ or AKT abolishes the effects of SKF-96365 on cancer cells, suggesting a critical role of the CaMKIIγ/AKT signaling pathway in SFK-96365-induced biological effects^[2].In Vivo: SKF-96365 inhibits CRC cell growth in vivo. SKF-96365 treatment results in a de


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Purity:98%
MWt:434.5771
Formula:C25H34N6O
SMILES:O=C(C1CCC1)NCCCNC2=NC(NC3=CC4=C(CN(C)CC4)C=C3)=NC=C2C5CC5
Pathway:Autophagy;
Mechanisms:ULK;
Research Area:Cancer
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